Dr INVIVO 4D 3D Bioprinter

Innovative and modular 3D bioprinting for a wide range of biofabrication applications. Modular dual print heads allow a choice of biofilament extruders and syringe and pneumatic dispensers to handle many biomaterials. Sterility maintained with HEPA filtration and UV sterilising lamps.

Manufacturer

Rokit Healthcare

ROKIT HEALTHCARE is a global healthcare company committed to providing an effective autologous organ regeneration platform using its proprietary biofabrication technologies across all types of applicable diseases in the field of regenerative medicine. Through a convergence of know-how’s and innovation in the areas of R&D (i.e. 4D bioprinting, autologous stem cell technologies, and human-derived biomaterials), surgical medicine, and regulatory affairs, ROKIT Healthcare believes in supplying customized organ regeneration platform services that will drastically change the way we trust and manage the health of our own body.

Key Features

  • Modular Dual Print Heads
  • Wide Temperature Range
  • Sterile Chamber for High Cell Viability
  • Reliable High Resolution Printing
  • Easy Touch Screen Interface
  • Supports Many Biomaterials
  • Dr. INVIVO 4D2 guarantees optimal cell growth environments
  • Customer-proven high cell viability and proliferation
  • Built-in clean-bench environment: HEPA-14 filter + UV Sterilisation
  • Medical-grade air filter for pneumatic pressure

Introducing Dr INVIVO 4D

The Rokit Dr INVIVO 4D bioprinter is a flexible, reliable and intuitive platform for enhancing complex, precision-based tissue engineering and regenerative medicine research. Rokit have developed Dr INVIVO 4D as a comprehensive solution for biomedical researchers and material engineers to pattern cells, biomolecules, and polymers.

Dr INVIVO 4D has been designed with a modular, dual print head system, allowing a wide range of biomaterials to be handled with ease. Materials can be deposited using 3 types of printing technology, including syringe dispenser, filament extruder, and hot-melting pneumatic dispenser. With the widest printing and bed temperature range available, complex multi-material 3D composite structures, from tissues to novel biocompatible materials can be fabricated.

Sterility and high cell viability is ensured by its closed chamber, with HEPA filters and UV sterilising lamps. Dr INVIVO is also easy to use, with a user-friendly touch screen interface, automated setup, and a remote monitoring system.

 

 

Sterile Environment for High Cell Viability

The printing chamber of the Dr INVIVO 4D bioprinter is a closed environment with an integrated clean bench system, consistently providing an optimal environment for cell growth. Cleanliness and sterility are maintained with an advanced H14 HEPA air filtration system and a UV sterilising lamp. Air filtration and UV sterilisation can be easily controlled with Dr INVIVO 4D’s touch screen interface. Medical-grade air filters are also used in the air pressure system for the optional pneumatic dispenser, further ensuring a contamination free printing environment.

The hygienic features of the Dr INVIVO 4D helps to ensure a high cell viability when bioprinting. Bacterial contamination is reduced up to 99.9%, and a cell viability of greater than 90% is maintained for up to 3 days.

User Friendly and Convenient Operation

Rokit's Dr INVIVO 4D bioprinter is easy and intuitive to operate, with a user-friendly touch screen display. A simple graphical interface guides users through the setup procedure and allows the printing status to be monitored. Common setup tasks such as bed levelling are automated. An integrated camera allows users to visually monitor the progress of prints even when away from the printer.

Prints are prepared and configured with Rokit's NewCreatorK slicing software. NewCreatorK allows users to load CAD designed 3D models, position and arrange them on the printing bed, and configure printing options. Prints can then be uploaded to the Dr INVIVO 4D via USB or Wi-Fi connection.

Temperature control and Pressure control

In its entirety, Dr. INVIVO 4D2 supports printing temperature from below zero up to 350 ℃ and a pressure up to 10 bar with dedicated temperature control and air compressor powerhouses provided in addition to the main printer unit.

  • Bed(-5℃~80℃)
  • Syringe(-5℃~80℃)
  • Filament(RT~250℃)
  • Hot-melting(RT~350℃)

Product range

Dr INVIVO 4D 3D Bioprinter
HumaTein™ Extracellular Matrix

Options

Modular Dual Print Head Design

The Invivo 3D Bioprinter has been designed for maximum flexibility, with modular dual print heads. Filament extruders, syringe dispensers and pneumatic dispensers are all available, and can be quickly and easily exchanged during setup. The standard Invivo system can be configured with a filament extruder and syringe dispenser, and can be upgraded with the pneumatic dispenser, enchanted temperature control and a heated bed.

Rokit's Filament Extruder (Included)

Rokit's filament extruder is suitable for a range of synthetic polymers such as PCL, PLGA, PLLA, PLA, and many more. The extruder can have a 0.2mm or 0.4mm nozzle, and heat filaments at up to 250°C.

The Invivo Syringe Dispenser (Included)

The Invivo syringe dispenser can handle a variety of bioinks, powder mixtures such as hydroxyapatite and chitosan, and hydrogels such as collagen, gelatin and fibrin. Rokit's proprietary dispensing technology improves cell viability when dispensing bioinks. Dispensing temperature control between -5°C - 80°C and dedicated UV curing lamps can be added as upgrades.

Pneumatic Dispenser (Optional)

An optional pneumatic dispenser for working with various types of polymers and high-viscosity materials requiring temperature and air pressure controller is also available. Material can be deposited at up to 350°C, and at 10 bar of pressure, making the pneumatic dispenser suitable for medical-grade polymers.

Downloads

Dr INVIVO 4D 3D Bioprinter Brochure

Dr INVIVO 4D 3D Bioprinter Brochure

If you would like to find out more about the innovative bioprinting technology in the Dr INVIVO 4D Bioprinter, contact the CN Tech team today. We are always keen to discuss new biofabrication applications in this rapidly developing field. Contact us today!