BI-2500 Series
Ideal system for developing biosensors in your research. Its flexible design allows an upgrade path for electrochemical SPR or chemical vapor (gas) SPR combination studies.
Manufacturer
Biosensing Instrument
Biosensing Instrument (BI) provides biophysical tools to accelerate drug discovery research. They offer the traditional Surface Plasmon Resonance (SPR) tools which provides easily interchangeable application modules that enables liquid-phase SPR, gas-phase SPR, and electrochemical-enhanced SPR studies all on one instrument. The award winning SPR microscopy (SPRm) instrument integrates optical microscopy with SPR technology allowing the simultaneous study of label-free binding kinetics of membrane proteins with whole cells.
Surface Plasmon Resonance Explained
Key Features
- Three-channel SPR detection module - Provides greater flexibility and faster assay development, doubling the throughput over two-channel SPR systems
- Innovative multi-module design - Provides users with maximum flexibility to choose amongst various analysis modules for electrochemistry and chemical vapor applications
- Wide dynamic range and high sensitivity - High sensitivity (<10-4 degrees) for both large and small molecules (<100 Daltons) enables users to measure binding constants down to a few pM-1
- Broad response time - For slow (hours) and fast (< ms) kinetic processes
- Cost effective - System has been designed with affordability in mind, brings SPR technology to your lab on your budget and with your own assay development schedule
Base Station
| Light Source | Two low coherent light sources (670nm) |
| Detection Speed | 4 ms |
| Incident Angle Ranges | 40 - 47 Deg (gas) 67 - 81 Deg (liquid) |
| Refractive Index Ranges | 1.00 -1.40 |
| Baseline Noise | <0.06 RU RMS (0.01 mDeg RMS) |
| Baseline Drift | 1RU/hr (0.17 mDeg/hr) (when ambient drifts <1°C/hr) |
| Measurement Ranges | Association rate constant ka: up to 108 M-1 s-1 Dissociation rate constant kd: 10-6 to 1 s-1 KD: 1pM to 1mM Active Concentration: 1pM to 1mM |
| Molecular Weight Cutoff | 100 Da |
| Temperature Control | Control accuracy at 0.01 degrees Range at +/- 5 degrees at room temperature |
| PC Interface | USB 3.0 |
| Data IO Port | IO ports for sending and receiving raw signals with other equipment |
| Outer Dimension and Weight | 335 (w) x 250 (h) x 515 (d) mm and 11.5kg |
| Power Supply | 110-230 V 50/60 Hz |
Fluid Handling
| Sample Channels | 3 channels |
| Flow Cell Material | PEEK (biologically compatible) |
| Flow Rate | 1.0 to 150μL/min (application dependent) |
| Buffer Handling | Dual syringes driven by programmable infusion pump Providing >8 hours of continuing operation |
| Sample Injection Volume | 10 to 500μL (application dependent) |
| Sample Injection Methods | Manual |
| Channel Volume | <32 nL |
| Injection Rise Time | < 0.2 s |
| Analysis Module (standard) | 3 channel flow injection analysis module |
| Optional Modules | EC-SPR module for SPR measurement with electrochemistry EC-DualFlowTM for two channel flow through EC-SPR measurement Gas SPR module for chemical vapour SPR measurement |
Control System
| Computer Software | Windows OS; SPR Control software for real-time instrument control with programmable interaction assays for various application protocols; data analysis software for affinity, kinetics analysis. |
| Compliance | CE compliance; IQOQ certification |
Applications
Life Science
Our Flow injection technique and analysis modules can help you with drug discovery and development, protein-protein/ protein-DNA/ protein-drug interaction studies, gene assays, immunosensing, and more.
Electrochemistry
Our Electrochemical SPR technique and analysis modules can help you with a variety of electro-analytical applications such as anodic stripping analysis, electropolymerization, electrodeposition, redox-related conformational change, and more.
Chemical Vapour Sensing
Our Gas Phase SPR technique and analysis modules can help you study fundamental solid-gas interface interactions, detect toxic molecules in the environment, perform various chemical analysis for medical research, and more.
Environment, Food & Beyond
Our BI SPR techniques can help you with broader applications such as food safety, quality control, environmental monitoring, or the development of new high-performance and coupled SPR techniques.
Downloads
BI-2500 Brochure
Environment, Food & Beyond
Chemical Vapour Sensing
Electrochemistry
Life Science
Service Support
Comprehensive repairs and servicing
Annual Support Programs
Your metrology instrumentation is a major investment that is critical to your business operation and success. In today’s competitive climate, it is more important than ever to extend the functionality and peak performance of your metrology equipment years beyond the expiration of your factory warranty. CN Tech’s Support Programs will help ensure that your investment is protected, and that you and your instrument’s are always operating at peak performance.
With over 20 years’ experience servicing and repairing you can be assured that your system is in safe hands. The independent services we offer include system relocation, maintenance visits, parts and consumables, and break down interventions.
CN Tech’s Support Programs are an economical way to guarantee optimal working condition:
- Annual Preventive Maintenance
- Priority Technical Assistance
- Preferred Parts Availability
- On-Site User Training
- Remote Diagnostics
- No surprise repair expense and much more!
Support Contact Example
An example of our service and support contracts are shown below:
Metrology & Instrumentation Annual Support Programs 2024/25
CN Tech's Support Programs will help ensure that your investment is protected, and that you and your instrument’s are always operating at peak performance.